<span id="v9r9v"><video id="v9r9v"></video></span>
<strike id="v9r9v"><video id="v9r9v"></video></strike>
<th id="v9r9v"></th>
<th id="v9r9v"></th>
<span id="v9r9v"><video id="v9r9v"></video></span>
<progress id="v9r9v"><noframes id="v9r9v"><span id="v9r9v"><noframes id="v9r9v">
您的位置:首頁>>分析化學>>藥物分析標準品>>Z4900 ZM-447439 TRIHYDRATE 331771-20-1
Cat. Number
Z4900
Chemical Name
Z4900 ZM-447439 TRIHYDRATE 331771-20-1
CAS Number
331771-20-1
Mol. Formula
C29H31N5O4 ? 3H2O
Mol. Weight
567.63
Qty 1
1mg
Qty 2
25mg
Appearance
White to Off-white Powder
Application Notes
≥99%
Solubility
DMSO 103 mg/mL (200.54 mM) Water Insoluble Ethanol Insoluble
Storage condition
-20°C
References

ZM-447439 inhibits aurora kinases A and B (AurA, AurB), preventing mitotic spindle formation and proper completion of mitosis. This compound exhibits anticancer activity, inducing hyperploidy and apoptosis in osteosarcoma cells and inhibiting growth in mesothelioma cells. ZM-447439 also induces apoptosis and inhibits expression of AurB and H3-P protein in cervical cancer cells, suppressing growth and survival.


References

Tavanti E, Sero V, Vella S, et al. Preclinical validation of Aurora kinases-targeting drugs in osteosarcoma. Br J Cancer. 2013 Nov 12;109(10):2607-18. PMID: 24129234.

Baldini E, Tuccilli C, Prinzi N, et al. The dual Aurora kinase inhibitor ZM447439 prevents anaplastic thyroid cancer cell growth and tumorigenicity. J Biol Regul Homeost Agents. 2013 Jul-Sep;27(3):705-15. PMID: 24152827.

Crispi S, Fagliarone C, Biroccio A, et al. Antiproliferative effect of Aurora kinase targeting in mesothelioma. Lung Cancer. 2010 Dec;70(3):271-9. PMID: 20371132.


下一個:沒有了上一個:TOZASERTIB
在線咨詢 聯系方式 二維碼

服務熱線

021-60498804

掃一掃,關注我們

人妻a∨中文字幕,亚洲AV日韩AV永久无码绿巨人,一国产永久视频,2022一本久道久久综合狂躁,国产欧美日韩在线视频一区 日韩精品Aⅴ无码AV 狠狠久夜一区二区三区 亚洲国产精品无码高潮 精品无码一区二区三在线观看 專業选择!国际品质好吊操视频 中文字幕一区二区人妻本田岬 久久综合电影一区 日韩AV不卡一区二区三区无码 欧美色欧美亚洲日韩在线播放