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您的位置:首頁>>分析化學>>藥物分析標準品>>G7444 GSK-1070916 942918-07-2
Cat. Number
G7444
Chemical Name
G7444 GSK-1070916 942918-07-2
CAS Number
942918-07-2
Mol. Formula
C30H33N7O
Mol. Weight
507.63
Qty 1
1mg
Qty 2
10mg
Appearance
Yellow to off white powder
Application Notes
≥98%
Synonym
GSK1070916, NMI-900
Solubility
DMSO 93 mg/mL (183.2 mM) Ethanol 8 mg/mL (15.75 mM) Water Insoluble
Storage condition
-20°C
References

GSK-1070916 is an inhibitor of aurora kinases B and C (AurB/C) that exhibits anticancer chemotherapeutic activity. GSK-1070916 prevents AurB from phosphorylating serine 10 of histone H3. In cellular and animal models of lung cancer, GSK-1070916 inhibits cellular proliferation and induces tumor regression. In models of colon cancer, breast cancer, and leukemia, this compound inhibits cell division, induces apoptosis, and suppresses tumor growth.


References

Adams ND, Adams JL, Burgess JL, et al. Discovery of GSK1070916, a potent and selective inhibitor of Aurora B/C kinase. J Med Chem. 2010 May 27;53(10):3973-4001. PMID: 20420387.

Hardwicke MA, Oleykowski CA, Plant R, et al. GSK1070916, a potent Aurora B/C kinase inhibitor with broad antitumor activity in tissue culture cells and human tumor xenograft models. Mol Cancer Ther. 2009 Jul;8(7):1808-17. PMID: 19567821.


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