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您的位置:首頁>>分析化學>>藥物分析標準品>>T8006 TUBASTATIN A HYDROCHLORIDE 1310693-92-5
Cat. Number
T8006
Chemical Name
T8006 TUBASTATIN A HYDROCHLORIDE 1310693-92-5
CAS Number
1310693-92-5
Mol. Formula
C20H21N3O2 ? HCl
Mol. Weight
371.86
Qty 1
1mg
Qty 2
10mg
Appearance
White to off white powder
Application Notes
≥98%
Synonym
Tubastatin A HCl
Solubility
DMSO 67 mg/mL (199.76 mM) Water Insoluble Ethanol Insoluble
Storage condition
-20°C
References

Tubastatin A is an inhibitor of class IIb histone deacetylases (HDACs), such as HDAC6 and HDAC10. Tubastatin A exhibits cardioprotective and anticancer chemotherapeutic activities. In vivo, tubastatin A decreases levels of α-tubulin and protects against atrial fibrillation-related atrial remodeling. Additionally, tubastatin A restores expression of primary cilia and decreases cell proliferation and growth in cholangiocarcinoma cells; in similar animal models, this compound inhibits tumor growth.


References

Zhang D, Wu CT, Qi X, et al. Activation of histone deacetylase-6 induces contractile dysfunction through derailment of α-tubulin proteostasis in experimental and human atrial fibrillation. Circulation. 2014 Jan 21;129(3):346-58. PMID: 24146251.

Gradilone SA, Radtke BN, Bogert PS, et al. HDAC6 inhibition restores ciliary expression and decreases tumor growth. Cancer Res. 2013 Apr 1;73(7):2259-70. PMID: 23370327.


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