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您的位置:首頁>>分析化學>>藥物分析標準品>>T6933 TRICHOSTATIN A 58880-19-6
Cat. Number
T6933
Chemical Name
T6933 TRICHOSTATIN A 58880-19-6
CAS Number
58880-19-6
Mol. Formula
C17H22N2O3
Mol. Weight
302.37
Qty 1
1mg
Qty 2
5mg
Appearance
Beige Powder
Application Notes
≥98%
Synonym
TSA
Melting Pt.
150-151°C
Solubility
Soluble in lower alchols. Slightly soluble in chloroform, ethyl acetate, acetone and benzene.
Storage condition
-20°C
References

Trichostatin A is an inhibitor of class I and II HDACs that exhibits anticancer and immunomodulatory activities. Trichostatin A induces cell cycle arrest, increases phosphorylation of JNK, downregulates activity of MCM-2, induces apoptosis, and inhibits proliferation of colon cancer cells. Trichostatin A also enhances differentiation and activity of CD4+ Foxp3+ Treg cells. Additionally, trichostatin A alters mammalian RNA splicing.

Trichostatin A also alters RNA splicing.


References

Liu Y, He G, Wang Y, et al. MCM-2 is a therapeutic target of Trichostatin A in colon cancer cells. Toxicol Lett. 2013 Jul 31;221(1):23-30. PMID: 23770000.

Do?as C, Fritz M, Manríquez V, et al. Trichostatin A promotes the generation and suppressive functions of regulatory T cells. Clin Dev Immunol. 2013;2013:679804. PMID: 23737814.

Cecconi D, Donadelli M, Rinalducci S,et al. Proteomic analysis of pancreatic endocrine tumor cell lines treated with the histone deacetylase inhibitor trichostatin A. Proteomics. 2007 May;7(10):1644-53. PMID: 17443844.


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