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您的位置:首頁>>分析化學>>藥物分析標準品>>T5060 TMP-269 1314890-29-3
Cat. Number
T5060
Chemical Name
T5060 TMP-269 1314890-29-3
CAS Number
1314890-29-3
Mol. Formula
C25H21F3N4O3S
Mol. Weight
514.52
Qty 1
1mg
Qty 2
25mg
Application Notes
≥98%
Solubility
DMSO 100 mg/mL (194.35 mM) Ethanol 2 mg/mL warmed (3.88 mM) Water Insoluble
Storage condition
-20°C
References

TMP-269 is an inhibitor of class II histone deacetylases (HDACs) that exhibits anticancer activity. In intestinal epithelial cells, TMP-269 inhibits cell cycle progression and cell proliferation. In multiple myeloma cells, this compound enhances carfilzomib-induced apoptosis.


References

Kikuchi S, Suzuki R, Ohguchi H, et al. Class IIa HDAC inhibition enhances ER stress-mediated cell death in multiple myeloma. Leukemia. 2015 Mar 24. [Epub ahead of print]. PMID: 25801913.

Sinnett-Smith J, Ni Y, Wang J, et al. Protein kinase D1 mediates class IIa histone deacetylase phosphorylation and nuclear extrusion in intestinal epithelial cells: role in mitogenic signaling. Am J Physiol Cell Physiol. 2014 May 15;306(10):C961-71. PMID: 24647541.


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