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您的位置:首頁>>分析化學>>藥物分析標準品>>S1069 SCRIPTAID 287383-59-9
Cat. Number
S1069
Chemical Name
S1069 SCRIPTAID 287383-59-9
CAS Number
287383-59-9
Mol. Formula
C18H18N2O4
Mol. Weight
326.35
Qty 1
1mg
Qty 2
5mg
Appearance
Off white powder
Application Notes
≥98%
Synonym
CGK1026, Scriptide
Solubility
Soluble in DMSO (1mg/mL) or methanol.
Storage condition
4°C
References

Scriptaid is an inhibitor of histone deacetylases that exhibits anticancer activity. In non-small cell lung cancer (NSCLC) cells, scriptaid downregulates expression of Chk1. In glioma cells, scriptaid increases activation of JNK and p38 MAPK, expression of p21 and p27, and activity of Ras; it also decreases activity of telomerase, inducing apoptosis and decreasing proliferation. In somatic cell nuclear transfer, scriptaid improves the quality of cloned mouse embryos.


References

Bui HT, Seo HJ, Park MR, et al. Histone deacetylase inhibition improves activation of ribosomal RNA genes and embryonic nucleolar reprogramming in cloned mouse embryos. Biol Reprod. 2011 Nov;85(5):1048-56. PMID: 21753193.

Brazelle W, Kreahling JM, Gemmer J, et al. Histone deacetylase inhibitors downregulate checkpoint kinase 1 expression to induce cell death in non-small cell lung cancer cells. PLoS One. 2010 Dec 14;5(12):e14335. PMID: 21179472.

Sharma V, Koul N, Joseph C, et al. HDAC inhibitor, scriptaid, induces glioma cell apoptosis through JNK activation and inhibits telomerase activity. J Cell Mol Med. 2010 Aug;14(8):2151-61. PMID: 19583803.


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