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您的位置:首頁>>分析化學>>藥物分析標準品>>S0344 SALERMIDE 1105698-15-4
Cat. Number
S0344
Chemical Name
S0344 SALERMIDE 1105698-15-4
CAS Number
1105698-15-4
Mol. Formula
C26H22N2O2
Mol. Weight
394.47
Qty 1
5mg
Qty 2
25mg
Appearance
Bright yellow solid
Application Notes
≥98%
Solubility
DMSO 78 mg/mL (197.73 mM) Ethanol 7 mg/mL warmed (17.74 mM) Water Insoluble
Storage condition
-20°C
References

Salermide is an inhibitor of sirtuins that exhibits anti-parasitic and anticancer chemotherapeutic activities. In Schistosoma mansoni, salermide decreases egg-laying activity, disrupts morphology of reproductive organs, and induces apoptosis and cell death. In breast cancer cells, salermide downregulates expression of sirtuin1, causing increases in p53 acetylation and cell death; additionally, salermide upregulates expression of DR5, ATF3, ATF4, and CHOP. Salermide also induces apoptosis in non-small cell lung cancer (NSCLC) cells) and inhibits tumor growth across a variety of animal models.


References

Lancelot J, Caby S, Dubois-Abdesselem F, et al. Schistosoma mansoni Sirtuins: characterization and potential as chemotherapeutic targets. PLoS Negl Trop Dis. 2013 Sep 12;7(9):e2428. PMID: 24069483.

Dastjerdi MN, Salahshoor MR, Mardani M, et al. The apoptotic effects of sirtuin1 inhibitor on the MCF-7 and MRC-5 cell lines. Res Pharm Sci. 2013 Apr;8(2):79-89. PMID: 24019817.

Liu G, Su L, Hao X, et al. Salermide up-regulates death receptor 5 expression through the ATF4-ATF3-CHOP axis and leads to apoptosis in human cancer cells. J Cell Mol Med. 2012 Jul;16(7):1618-28. PMID: 21801305.

Lara E, Mai A, Calvanese V, Altucci L, et al. Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect. Oncogene. 2009 Feb 12;28(6):781-91. Erratum in: Oncogene. 2009 Feb 26;28(8):1168. Inhof, A [corrected to Imhof, A]. PMID: 19060927.


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