<span id="v9r9v"><video id="v9r9v"></video></span>
<strike id="v9r9v"><video id="v9r9v"></video></strike>
<th id="v9r9v"></th>
<th id="v9r9v"></th>
<span id="v9r9v"><video id="v9r9v"></video></span>
<progress id="v9r9v"><noframes id="v9r9v"><span id="v9r9v"><noframes id="v9r9v">
您的位置:首頁>>分析化學>>藥物分析標準品>>I7559 ISOLIQUIRITIGENIN, NATURAL 961-29-5
Cat. Number
I7559
Chemical Name
I7559 ISOLIQUIRITIGENIN, NATURAL 961-29-5
CAS Number
961-29-5
Mol. Formula
C15H12O4
Mol. Weight
256.25
Qty 1
1mg
Qty 2
25mg
Appearance
Bright yellow powder
Application Notes
≥99%
Synonym
4,2’,4’-Trihydroxychalcone
Storage condition
4°C
References

Isoliquiritigenin is a chalcone with a wide variety of targets; it exhibits anticancer, anti-angiogenic, antioxidative, and neuroprotective activities. Isoliquiritigenin inhibits NMDA receptors, histone deacetylases (HDACs), VEGFR2, and NF-κB (via inhibition of IκB kinase). In vitro, this compound increases Nrf2 expression. Additionally, isoliquiritigenin downregulates expression of arachidonic acid-metabolizing enzymes cyclooxygenase-2 (COX-2) and phospholipase A2 (PLA2), increasing mitochondria- and/or caspase-mediated apoptosis, and inhibiting proliferation of breast cancer cells. Isoliquiritigenin also modulates sirtuins and acts as a positive allosteric modulator at GABA-A receptors.


References

Chen H, Zhang B, Yuan X, et al. Isoliquiritigenin-induced effects on Nrf2 mediated antioxidant defence in the HL-60 cell monocytic differentiation. Cell Biol Int. 2013 Nov;37(11):1215-1224. PMID: 23881796.

Wang Z, Wang N, Han S, et al. Dietary compound isoliquiritigenin inhibits breast cancer neoangiogenesis via VEGF/VEGFR-2 signaling pathway. PLoS One. 2013 Jul 5;8(7):e68566. PMID: 23861918.

Li Y, Zhao H, Wang Y, et al. Isoliquiritigenin induces growth inhibition and apoptosis through downregulating arachidonic acid metabolic network and the deactivation of PI3K/Akt in human breast cancer. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):37-48. PMID: 23747687.

Yuan X, Zhang B, Gan L, et al. Involvement of the mitochondrion-dependent and the endoplasmic reticulum stress-signaling pathways in isoliquiritigenin-induced apoptosis of HeLa cell. Biomed Environ Sci. 2013 Apr;26(4):268-76. PMID: 23534467.

Orlikova B, Schnekenburger M, Zloh M, et al. Natural chalcones as dual inhibitors of HDACs and NF-κB. Oncol Rep. 2012 Sep;28(3):797-805. PMID: 22710558.

Cho S, Kim S, Jin Z, et al. Isoliquiritigenin, a chalcone compound, is a positive allosteric modulator of GABAA receptors and shows hypnotic effects. Biochem Biophys Res Commun. 2011 Oct 7;413(4):637-42. PMID: 21945440.

Kawakami Z, Ikarashi Y, Kase Y. Isoliquiritigenin is a novel NMDA receptor antagonist in kampo medicine yokukansan. Cell Mol Neurobiol. 2011 Nov;31(8):1203-12. PMID: 21691759.


下一個:LBH-589上一個:ENTINOSTAT
在線咨詢 聯系方式 二維碼

服務熱線

021-60498804

掃一掃,關注我們

人妻a∨中文字幕,亚洲AV日韩AV永久无码绿巨人,一国产永久视频,2022一本久道久久综合狂躁,国产欧美日韩在线视频一区 日韩精品Aⅴ无码AV 狠狠久夜一区二区三区 亚洲国产精品无码高潮 精品无码一区二区三在线观看 專業选择!国际品质好吊操视频 中文字幕一区二区人妻本田岬 久久综合电影一区 日韩AV不卡一区二区三区无码 欧美色欧美亚洲日韩在线播放