<span id="v9r9v"><video id="v9r9v"></video></span>
<strike id="v9r9v"><video id="v9r9v"></video></strike>
<th id="v9r9v"></th>
<th id="v9r9v"></th>
<span id="v9r9v"><video id="v9r9v"></video></span>
<progress id="v9r9v"><noframes id="v9r9v"><span id="v9r9v"><noframes id="v9r9v">
您的位置:首頁>>分析化學>>藥物分析標準品>>E5477 ENTINOSTAT 209783-80-2
Cat. Number
E5477
Chemical Name
E5477 ENTINOSTAT 209783-80-2
CAS Number
209783-80-2
Mol. Formula
C21H20N4O3
Mol. Weight
376.41
Qty 1
1mg
Qty 2
100mg
Appearance
Yellow Powder
Application Notes
≥98%
Synonym
SNDX-275, MS-275, MS275
Melting Pt.
159-160°C
Storage condition
Ambient
References

Entinostat is a benzamide derivative that inhibits histone deacetylase 1 (HDAC1); entinostat exhibits anticancer chemotherapeutic, anti-metastatic, and neuroprotective properties. In vitro, entinostat increases transcription of E-cadherin and decreases transcription of N-cadherin, decreasing tubulin-based microtentacles, reversing epithelial-to-mesenchymal transition (EMT) and inhibiting cell migration. In cellular and animal models, this compound upregulates natural killer cell activating receptor NKG2D, increasing the ability of natural killer cells to destroy cancer cells. Additionally, entinostat downregulates cellular FLICE-inhibiting protein (c-FLIP), increasing caspase activation and inducing apoptosis in animal models. Inhibition of HDAC1 in the nucleus accumbens (NAcc) inhibits cocaine-induced plasticity and behavioral changes in rodent models. Entinostat also decreases amyloid-β (Aβ) deposition in the hippocampus and cortex of animal models.


References

Shah P, Gau Y, Sabnis G. Histone deacetylase inhibitor entinostat reverses epithelial to mesenchymal transition of breast cancer cells by reversing the repression of E-cadherin. Breast Cancer Res Treat. 2013 Dec 5. [Epub ahead of print]. PMID: 24305977.

Zhu S, Denman CJ, Cobanoglu ZS, et al. The Narrow-Spectrum HDAC Inhibitor Entinostat Enhances NKG2D Expression Without NK Cell Toxicity, Leading to Enhanced Recognition of Cancer Cells. Pharm Res. 2013 Nov 8. [Epub ahead of print]. PMID: 24203492.

Kennedy PJ, Feng J, Robison AJ, et al. Class I HDAC inhibition blocks cocaine-induced plasticity by targeted changes in histone methylation. Nat Neurosci. 2013 Apr;16(4):434-40. PMID: 23475113.

Rao-Bindal K, Koshkina NV, Stewart J, et al. The histone deacetylase inhibitor, MS-275 (entinostat), downregulates c-FLIP, sensitizes osteosarcoma cells to FasL, and induces the regression of osteosarcoma lung metastases. Curr Cancer Drug Targets. 2013 May;13(4):411-22. PMID: 23410027.

Zhang ZY, Schluesener HJ. Oral administration of histone deacetylase inhibitor MS-275 ameliorates neuroinflammation and cerebral amyloidosis and improves behavior in a mouse model. J Neuropathol Exp Neurol. 2013 Mar;72(3):178-85. PMID: 23399896.


下一個:ISOLIQUIRITIGENIN, NATURAL上一個:CURCUMIN
在線咨詢 聯系方式 二維碼

服務熱線

021-60498804

掃一掃,關注我們

人妻a∨中文字幕,亚洲AV日韩AV永久无码绿巨人,一国产永久视频,2022一本久道久久综合狂躁,国产欧美日韩在线视频一区 日韩精品Aⅴ无码AV 狠狠久夜一区二区三区 亚洲国产精品无码高潮 精品无码一区二区三在线观看 專業选择!国际品质好吊操视频 中文字幕一区二区人妻本田岬 久久综合电影一区 日韩AV不卡一区二区三区无码 欧美色欧美亚洲日韩在线播放