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您的位置:首頁>>分析化學>>藥物分析標準品>>C0048 CAMBINOL 14513-15-6
Cat. Number
C0048
Chemical Name
C0048 CAMBINOL 14513-15-6
CAS Number
14513-15-6
Mol. Formula
C21H16N2O2S
Mol. Weight
360.43
Qty 1
5mg
Qty 2
25mg
Appearance
White to off white powder
Application Notes
≥98%
Synonym
SIRT 1/2 inhibitor IV, SIRT1 Inhibitor II, NSC112546, SIRT2 Inhibitor VI.
Solubility
Soluble in DMSO (≥10 mg/ml), and ethanol (5 mg/ml)
Storage condition
-20°C
References

Cambinol is an inhibitor of sirtuins, particularly sirtuin1. Cambinol exhibits anti-inflammatory and anticancer chemotherapeutic activities. In various cell lines, cambinol suppresses MAPK and MEK signaling and inhibits expression of pro-inflammatory cytokines such as IL-1β, IL-6, TNF-α, and IFN-γ. Additionally, cambinol improves survival of animal models of endotoxic shock and septic shock. In vitro, cambinol inhibits proliferation and increases differentiation and senescence in hepatocellular carcinoma cells. In vivo, cambinol inhibits xenograft growth in models of hepatocellular carcinoma and Burkitt’s lymphoma.


References

Lugrin J, Ciarlo E, Santos A, et al. The sirtuin inhibitor cambinol impairs MAPK signaling, inhibits inflammatory and innate immune responses and protects from septic shock. Biochim Biophys Acta. 2013 Jun;1833(6):1498-510. PMID: 23499872.

Portmann S, Fahrner R, Lechleiter A, et al. Antitumor effect of SIRT1 inhibition in human HCC tumor models in vitro and in vivo. Mol Cancer Ther. 2013 Apr;12(4):499-508. PMID: 23339189.

Heltweg B, Gatbonton T, Schuler AD, et al. Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Res. 2006 Apr 15;66(8):4368-77. PMID: 16618762.


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