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您的位置:首頁>>分析化學>>藥物分析標準品>>E6397 EPZ6438 1403254-99-8
Cat. Number
E6397
Chemical Name
E6397 EPZ6438 1403254-99-8
CAS Number
1403254-99-8
Mol. Formula
C34H44N4O4
Mol. Weight
572.74
Qty 1
1mg
Qty 2
100mg
Appearance
white powder
Application Notes
≥99%
Synonym
E7438, Tazemetostat,
Solubility
DMSO 5 mg/mL warmed (8.72 mM) Water Insoluble Ethanol Insoluble
Storage condition
-20°C
References

EPZ-6438 is an inhibitor of EZH2, a histone methyltransferase (HMT) responsible for methylation of lysine and arginine residues and controls gene transcription fidelity in cells. EPZ-6438 displays anticancer chemotherapeutic activity in in vivo models by inducing regression of malignant or atypical teratoid rhabdoid tumors containing altered or mutant SWI/SNF ATP-dependent chromatin remodelers.


References

Knutson SK, Warholic NM, Wigle TJ, et al. Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2. Proc Natl Acad Sci U S A. 2013 May 7;110(19):7922-7. PMID: 23620515.


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