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您的位置:首頁>>生化試劑>>小分子化合物>>10-2728 (±)-N-Methyl-γ-[4-(trifluoromethyl)phenoxy]benzenepropanamine hydrochloride 56296-78-7
Cat. Number
10-2728
Chemical Name
10-2728 (±)-N-Methyl-γ-[4-(trifluoromethyl)phenoxy]benzenepropanamine hydrochloride 56296-78-7
CAS Number
56296-78-7
Mol. Formula
C17H18F3NO ? HCl
Mol. Weight
345-79
Qty 1
100mg
Qty 2
1g
Appearance
White solid
Application Notes
98% by TLC NMR (Conforms)
Synonym
LY-110,140
Solubility
Soluble in DMSO (up to 35 mg/ml) or in Water (up to 4 mg/ml)
Storage condition
RT (des.)
Stability
Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
References

Fluoxetine HCl (56296-78-7) is a selective serotonin reuptake inhibitor (SSRI) with high selectivity for the serotonin transporter (Kd=0.81 nM) over the norepinephrine (Kd=240 nM) and dopamine (Kd=3.6 mM) transporters.1 A clinically useful antidepressive agent.2 Has shown some potential in autism spectrum disorders.3Attenuates neuroinflammation in early brain injury after subarachnoid hemorrhage.4 Orally active and active in vivo. Increases proliferation of neuronal precursors derived from human embryonic stem cells, inducing differentiation and strongly enhancing neuronal characteristics.5

References/Citations

1) Tatsumi et al. (1997), Pharmacological profile of antidepressants and related compounds at human monoamine transporters; Eur. J. Pharmacol., 340 249
2) Benfield et al. (1986), Fluoxetine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness; Drugs, 32 481
3) Benvenuto et al. (2013), Pharmacotherapy of autism spectrum disorders; Brain Dev., 35 119
4) Liu et al. (2018), Fluoxetine attenuates neuroinflammation in early brain injury after subarachnoid hemorrhage: a possible role for the regulation of TLR4/MyD88/NFkB signaling pathway; J. Neuroinflammation, 15 347
5) Chang et al. (2010), Increased cellular turnover in response to fluoxetine in neurona precursors derived from human embryonic stem cells; Prog. Int. J. Dev. Biol., 54 707

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氟西汀鹽酸鹽  英文名稱Fluoxetine HCl ,貨號10-2728 上?;菡\提供100mg 1g 氟西汀鹽酸鹽 Fluoxetine HCl,美國focus原裝進口,咨詢電話021-60498804

氟西汀鹽酸鹽  英文名稱Fluoxetine HCl ,貨號10-2728 上?;菡\提供100mg 1g 氟西汀鹽酸鹽 Fluoxetine HCl,美國focus原裝進口,咨詢電話021-60498804

 

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