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您的位置:首頁>>生化試劑>>小分子化合物>>10-2621 3-[1-[3-(Dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione 133053-19-7
Cat. Number
10-2621
Chemical Name
10-2621 3-[1-[3-(Dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione 133053-19-7
CAS Number
133053-19-7
Mol. Formula
C26H26N4O3
Mol. Weight
442.51
Qty 1
1mg
Qty 2
5mg
Appearance
Red-orange solid
Application Notes
98% by HPLC NMR (Conforms)
Synonym
3-[1-[3-(Dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
Solubility
Soluble in DMSO (up to 20 mg/ml)
Storage condition
-20°C (des.)
Stability
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
References

Go-6983 (133053-19-7) potent and pan-specific, ATP-competitive protein kinase C inhibitor. PKC isotype IC50s= 7, 7, 6, 10 and 60 nM for PKC α, β, γ, δ, ζ respectively.1Suppresses stress induced HSP27 disassociation.2  Maintains rat embryonic stem cell pluripotency.3 Attenuates myocardial ischemia/reperfusion injury.4  

References/Citations

1) Gschwendt et al. (1996), Inhibition od protein kinas C mu by various inhibitors. Differentiation from protein kinas C isoenzymes; FEBS Lett., 392 77
2) Kato et al. (2001), Protein kinase inhibitors can suppress stress-induced dissociation of Hsp27; Cell Stress Chaperones, 6 16
3) Rajendran et al. (2013), Inhibition of protein kinas C signaling maintains rat embryonic stem cell pluripotency; J. Biol. Chem., 288 24351
4) Young et al. (2005), Go 6983: a fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury; Cardiovasc, Drug Rev., 23 255

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