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您的位置:首頁>>生化試劑>>小分子化合物>>10-2618 2,3-Bis[4-(2,3-epoxypropoxy)phenyl]propane 1675-54-3
Cat. Number
10-2618
Chemical Name
10-2618 2,3-Bis[4-(2,3-epoxypropoxy)phenyl]propane 1675-54-3
CAS Number
1675-54-3
Mol. Formula
C21H24O4
Mol. Weight
340.41
Qty 1
10mg
Qty 2
50mg
Appearance
White low melting point solid
Application Notes
95% by HPLC NMR (Conforms)
Synonym
Bisphenol A diglycidyl ether
Solubility
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 15 mg/ml)
Storage condition
-20°C (des.)
Stability
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
References

BADGE (1675-54-3) is a PPARγ antagonist with μM affinity in 3T3-L1 and 3T3-F442A preadipocyte cells. Selective over PPARδ and PPARα. Antagonizes the ability of rosiglitazone to stimulate transcriptional activity of PPARγ and abolishes its anti-inflammatory effects in a mouse model1. Induces apoptosis via PPARγ-independent mechanisms2. Induces adipogenesis in human and mouse mesenchymal stromal stem cells and in mouse 3T3-L1 preadipocytes at low nM concentrations via a PPARγ independent mechanism3. Increases osteoblastogenesis and bone mass in a mouse model4. Active in vivo.

References/Citations

1) Cuzzocrea et al. (2004), Rosiglitazone , a ligand of the peroxisome proliferator-activated receptor-gamma, reduces acute inflammation; Eur. J. Pharmacol., 483 79
2) Fehlberg et al. (2003), Bisphenol A diglycidyl ether-induced apoptosis involves Bax/Bid-dependent mitochondrial release of apoptosis-inducing factor (AIF), cytochrome c and Smac/DIABLO; Br. J. Pharmacol., 139 495
3) Chamorro-Garcia et al. (2012), Bisphenol A diglycidyl ether induces adipogenic differentiation of multipotent stromal stem cells through a peroxisome proliferator-activated receptor gamma-independent mechanism; Environ. Health Perspect., 120 984
4) Duque et al. (2013), Pharmacological inhibition of PPARgamma increases osteoblastogenesis and bone mass in male C57BL/6 mice; J. Bone Miner. Res., 28 639

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BADGE ,貨號10-2618上?;菡\提供10mg 50mg BADGE,美國focus原裝進口,咨詢電話021-60498804

BADGE ,貨號10-2618上?;菡\提供10mg 50mg BADGE,美國focus原裝進口,咨詢電話021-60498804

 

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