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您的位置:首頁>>生化試劑>>信號轉導>>辛伐他汀 Simvastatin
Cat. Number
10-1018
Chemical Name
辛伐他汀 Simvastatin
CAS Number
79902-63-9
Mol. Formula
C25H38O5
Mol. Weight
418.58
Qty 1
100mg
Qty 2
500mg
Appearance
White solid
Application Notes
98% by TLC NMR (Conforms)
Synonym
Mevinolin,2,2-Dimethyl-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester butanoic acid
Solubility
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 35 mg/ml).
Storage condition
-20°C
Stability
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
References

Simvastatin (79902-63-9) is a synthetic analog of lovastatin (cat.# 10-1222). Blocks cholesterol and isoprenoid biosynthesis via inhibition of HMG-CoA reductase1,2. Simvastatin induces apoptosis in various cell lines and causes cell cycle arrest in early G1 phase. Clinically useful antilipemic agent3.

References/Citations
1) Merck 14:8539
2) Hancock et al. (1989), All ras proteins are polyisoprenylated but only some are palmitoylated; Cell,57 1167
3) Ose et al. (2000), Lipid-altering efficacy and safety of simvastatin 80 mg/day: long-term experience in a large group of patients with hypercholesterolemia. World Wide Expanded Dose Simvastatin Study Group Clin. Cardiol. 23 39
4) Matsuzaka et al. (2016) Characterization and functional analysis of extracellular vesicles and muscle-abundant miRNA in C2C12 myocytes and Mdx mice; PLoS One 11(12) e0167811 [Focus Biomolecules Citation]

Focus Biomolecules cell signaling reagent supplier, structure Simvastatin | HMG-CoA reductase inhibitor | CAS 79902-63-9

辛伐他汀  英文名稱Simvastatin ,貨號10-1018 上?;菡\提供100mg 500mg 辛伐他汀 Simvastatin,美國focus原裝進口,咨詢電話021-60498804

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